Hyperbranched polymers download ebook pdf, epub, tuebl, mobi. Dendrimers are highly branched, starshaped macromolecules with nanometerscale dimensions. In recent years, starburst pamam dendrimers, a class of polyamidoamine polymers, have become an interesting alternative vector for nonviral delivery of dna in vitro and in vivo 16. Hyperbranched polymers figure 3 are polydisperse dendritic macromolecules that possess dendrimerlike properties but are prepared in a single synthetic polymerization step. With contributions from many of the worlds leading scientists in the field of dendritic research and development, dendrimers and other dendritic polymers. Dendritic polymers are belonging to a special class of macromolecules. Hybrid dendrimers linear polymers these are hybrids block or graft polymers of dendritic and linear polymers and having properties of both. Dendritic polymers have advantage in biomedical applications. Dendrimers and other dendritic polymers edited by jean m.
Request pdf dendrimers, dendrons, and dendritic polymers. Dendrimers, dendrons, and dendritic polymers discovery, applications, and the future donald a. Dendrimers in nanomedicine is a timely, welledited as well as masterly crafted book written by experts in the field. The series advances in dendritic macromolecules aims to cover the synthesis and supramolecular chemistry of dendritic or cascade supermolecules as well as their less perfect hyperbranched cousins. Discovery, applications, and the future dendrimer science has exploded onto the polymer science scene as the fourth major class of. Dendrimers are branched, synthetic polymers with layered architectures that show promise in several biomedical applications. Dendrimers and other dendritic polymers request pdf. Dendrimerbased drug delivery systems by yiyun cheng.
Frechet, 9780471638506, available at book depository with free delivery worldwide. Dendrimers, dendrons, and dendritic polymers dendrimer science has exploded onto the polymer science scene as the fourth major class of polymer architecture after the three traditional categories of. These dendritic polymers are analogous to protein, enzymes, and viruses, and are easily functionalized. Dendrimers, dendrons, and dendritic polymers ebook por. Of interest to academia and industry alike, this book covers the synthesis. The monomeric unit 1propargylbenzene3,5dimethanol contained the alkyne functionality, while the core 1,2bis2azidoethoxyethane and growing dendrimers presented the azide groups. The relationship of dendritic polymers to traditional polymer classes can be better. Dendrimers are novel and exciting class of highly branched threedimensional polymer in which growth emanates from a central core molecule such as ammonia, ethylenediamine, and polydiamine or benzene tricarboxylic acid chloride. Amphiphilic dendrimers they are built with two segregated sites of chain end, one half is electron donating and the other half is electron withdrawing. Readers will not only discover the current state of the science, but also gain valuable insights into fruitful directions for future research.
The unique properties of dendrimers, such as their high degree of branching, multivalency, globular architecture and welldefined molecular weight, make them. The images of dendrimers, with their beautiful snowflakelike structures, make it quite captivating. Starting with a historical overview, definitions and other fundamentals, it goes on to look at characterization, analysis and properties of dendrimers. This volume demonstrates the novel and varied growth in this topic and certainly pushes the supramolecular concepts of lehn into the budding supramacromolecular frontier. For example, polyester dendrimers are much more soluble in thf than the analogous linear polyester. Capturing the history of dendrimer discovery to the present day, this book addresses. The first category includes dendrimers and dendrons, and the latter includes dendronized polymers, hyperbranched. Dendrimer science has exploded onto the polymer science scene as the fourth major class of polymer architecture. Dendrimers, dendrons, and dendritic polymers ebook by donald. Dendrimers and other molecules can also be attached to periphery or can be encapsulated in their interior voids. The dendritic effect can be observed with any type of dendrimer, and for any type of property, eve dendrimers and hyperbranched polymers. In dendritic polymers, generally there are four main subgroups which are closely related to one another. Twentyfirst century polymer science after staudinger.
Frechet university of california, department of chemistry and materials sciences division, lawrence berkeley national laboratory, berkeley, ca, usa and donald a. The central core, which is shielded off from the outside by the dendritic wedges. When compared to other nano polymers, the characteristics of supramolecular pamam dendrimers in nanopolymer science has shown significant achievement in transporting drugs for molecular targeted. Dendrimers containing 1,4triazole linkages between each generation were grown divergently via the click chemistry inspired huisgen 1,3dipolar cycloaddition reaction in the presence of a cui catalyst.
In chapter 1 of this volume, hawker and wooley delineate the convergent growth approach to dendrimers, then relate their threedimensional architectures to different. Request pdf dendrimers and other dendritic polymers introductiongeneral commentsselfassemblycovalent bond formation methoddirect covalent bond. Dendritic molecules are characterized by structural perfection. Dendrimers possess unique structures and exhibit properties that differ dramatically from. Dendrimers and dendritic polymers in drug delivery. The reader is guided through the applications of dendrimers and dendritic polymers, the features of each, and the influence of dendritic structure on materials properties, such as the dendritic effect. Cascade molecules and dendrimers dendritic architectures perfection, defects, dispersity. Dendrimers and dendrons are monodisperse and usually highly symmetric, spherical compounds. The emergence of dendrimersdendritic polymers as a fourth major architecture and window to a new nanoperiodic system.
They are synthesized by stepwise chemical methods to give distinct generations g0, g1, g2, etc. Where the content of the ebook requires a specific layout, or contains maths or other special characters, the ebook will be available in pdf pbk format, which cannot be reflowed. Dendrimers as catalyst 56 dendritic polymers have been used in large amount as catalyst. Read dendrimers, dendrons, and dendritic polymers discovery, applications, and the future by donald a. Dendrimers and other molecules can either be attached to the periphery or can be encapsulated in their interior voids. Dendrimers clicked together divergently macromolecules. Construction of linear polymers, dendrimers, networks, and other polymeric architectures by copper. Everyday low prices and free delivery on eligible orders.
Lee dendrimers, dendrons, and dendritic polymers discovery, applications, and the future por donald a. Dendrimer chemistry provides an overview of the latest advances in the synthesis of dendrimers and other complex dendritic architectures. Similar to linear polymers, they composed of a large number of monomer units that were chemically linked together. They are imperfectly branched and have an average rather than precise number of terminal functional groups, but are more cost effective than the perfect dendrimer products.
Dendrimers and their applications as novel drug delivery carriers. Other controllable properties of dendrimers include toxicity, crystallinity, tectodendrimer formation, and chirality. Macromolecular rapid communications 2008, 29 12, 10521072. Due to their unique physical and chemical properties, dendrimers. Dendrimers and other dendritic polymers provides a detailed insight into dendritic polymers, and discusses all the known subclasses of dendritic polymers in addition to dendrons and dendrimers, including hyperbranched polymers, dendrigrafts and megamers. The dendritic effect illustrated with phosphorus dendrimers. The dendrimer structure can be divided into three parts. Dendrimers in nanomedicine crc press book nanomedicine can take advantage of the recent developments in nanobiotechnology research for the creation of platforms with superior drug carrier capabilities, selective responsiveness to the environment, unique contrast enhancement profiles, and improved accumulation at the disease site. Request pdf discovery of dendrimers and dendritic polymers. These nanoscopic polymers, characterized by regular dendritic branching, radial symmetry, and uniform size ranging from 411 nm, have excellent water solubility and biocompatibility in a broad range.
By regulating dendrimer synthesis, it is possible to precisely manipulate both their molecular weight and chemical composition, thereby allowing predictable tuning of their biocompatibility and pharmacokinetics. Dendrimers and other dendritic polymers ebook, 2001. Several other dendrimer families, such as the amides synthesized by schluter et al. Dramatic molecular weight enhancements visavis other dendrimer. The dendritic polymer had benefit in biomedical applications.
The field of dendritic molecules can be roughly divided into lowmolecular weight and highmolecular weight species. Conspectussupramolecular dendritic polymers sdps, which perfectly combine the advantages of dendritic polymers with those of supramolecular polymers, are a novel class of noncovalently bonded, highly branched macromolecules with threedimensional globular topology. Functional dendrimers, hyperbranched and star polymers. Lysine dendrimers and polymer brushes are used for drug and other e. Advances in dendritic macromolecules, volume 2 1st edition. U boas dendrimer science has exploded onto the polymer science scene as the fourth major class of polymer architecture. Dendrimers and other dendritic polymers wiley series in. Dendritic polymers and their potential applications.
Dendrimers are considered as the polymers of 21 st century the discovery and creation of new drugs is timely and costly process. These nanoscopic polymers, characterized by regular dendritic branching, radial symmetry, and uniform size ranging from 411 nm, have excellent water. These include some naturally occurring polysaccharides, synthetic hyperbranched or comb. Fundamental theory, chemistry and physics of the dendritic state synthetic strategies click. Obtained by complete monofunctionalization of the peripheral amines of a zerogeneration polyethyleneimine dendrimer, provide structurally diverse lamellar, columnar, and cubic selforganized lattices that are less readily available from other modified dendritic structures. Although dendrimers were originally proposed to be a cureall for medicine, it has taken longer than expected to fully appreciate their inherent structural shortcomings as well as potential. Dendrimers in nanomedicine 1st edition delphine felder. Dendrimers and their applications as novel drug delivery. Synthesizing the raw data needed for a wide variety of industrial applications, this work supplies uptodate advanced in research on star, hyperbranched and dendritic polymers.
Capturing the history of dendrimer discovery to the present day, this book addresses all the essential information for newcomers and those experienced in the field, including. Also, it is possible to make dendrimers watersoluble, unlike most polymers, by functionalizing their outer shell with charged species or other hydrophilic groups. Depending on the type of dendrimer, the core may have very different properties than the surrounding shell. Buy dendrimers and other dendritic polymers wiley series in polymer science by frechet isbn. Purchase advances in dendritic macromolecules, volume 5 1st edition. There are two major reasons for the advantage of using dendritic polymers. Because of their dynamicreversible nature, unique topological structure, and exceptional physicalchemical properties. Hyperbranched polymer pamam dendrimers dendritic polymer dendrimer molecule propylene imine. Dendrimermediated cell transfection in vitro springerlink. For example, see dendrimers and other dendritic polymers, eds. The series advances in dendritic macromolecules aims to cover the synthetic, as well as chemical, aspects of this expanding field.